Abstract submitted for 2018 FDA PhUSE Computational Sciences Symposium

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Use of the novel HistoGraphic software to visualize and analyze histopathology data from multiple toxicology studies

FDA PhUSE Computational Sciences Nonclinical Topics Working Group

The ability to aggregate and analyze histopathology data from multiple toxicology studies provides the opportunity to identify trends in target organ toxicities and lesions of concern, and to readily compare results across studies. The novel graphical display tool termed HistoGraphic, utilizing a “sunburst” format based on a hierarchical concentric ring structure, provides this functionality. As proof-of-concept, histopathology data from multiple toxicology studies were obtained from the European Union’s Innovative Medicines Initiative (IMI) eTOX consortium, which constitutes a database of legacy toxicity data from member pharmaceutical companies. HistoGraphic is highly interactive and provides the means for identifying major target organs for each compound, and can be searched by organ or lesion descriptor to rapidly identify findings of interest.