ACR Response Criteria

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The ACR (American College of Rheumatology) Criteria is a standard criteria to measure the effectiveness of various arthritis medications or treatments in clinical trials for Rheumatoid Arthritis.

The ACR is used to maximally discriminate effective treatment from placebo treatment in clinical trials. The ACR criteria is indicated as ACR 20, ACR 50 or ACR 70.

The ACR is reported as % improvement, comparing disease activity at two discrete time points (usually baseline and post-baseline comparison).

  • ACR20 is ≥ 20% improvement
  • ACR50 is ≥ 50% improvement
    • ACR50 responders include ACR20 responders
  • ACR70 is ≥ 70% improvement
    • ACR70 responders include ACR20 & ACR50 responders

Definition

The ACR Criteria is a dichotomous variable with a positive (=responder) or negative (=non-responder) outcome.

The ACR Criteria measures improvement in tender or swollen joint counts in improvement in at least three of the following parameters:

  1. patient assessment
  2. physician assessment
  3. pain scale
  4. disability/functional questionnaire
  5. acute phase reactant (ESR or CRP

ACR 20 has a positive outcome if 20% improvement in tender or swollen joint counts were achieved as well as a 20% improvement in at least three of the other five criteria.

ACR 50 has a positive outcome if 50% improvement in tender or swollen joint counts were achieved as well as a 50% improvement in at least three of the other five criteria.

ACR 70 has a positive outcome if 70% improvement in tender or swollen joint counts were achieved as well as a 70% improvement in at least three of the other five criteria.

SDTM Data

Analysis


Last revision by SaschaAhrweiler,07/1/2012